"Working with colleagues at LifeCanvas Technologies has opened an entirely new avenue of research for us. Our interest has focused on increasing the spatial resolution in magnetic resonance histology — microscopic imaging of the rodent brain, to allow studies of the mouse brain connectome. Using the clearing/light sheet with the Thy 1 mouse has yielded in the same specimen, diffusion tensor MRI images and the opportunity to validate specific motor pathways. Merging the two yields a sum that is far more than the individual parts. We see the light sheet data from our colleagues at LifeCanvas Technologies as a critical new complement to our MR methodologies. Our colleagues there have been more than helpful and we look forward to extended collaboration in the future."

"I am one of the early adopters of whole-brain clearing and imaging technologies and continue to be an enthusiastic developer myself. Currently, my group is focusing on applying brain-wide approaches to understand the central regulation of energy metabolism. I used to build my own device years ago but constant maintenance and repair of homemade devices simply aren't practical for fast-paced, high-throughput applications. Having a turn-key clearing/imaging system by LifeCanvas has been absolutely transformative and a blessing even for experienced users like us. The technology is state-of-the-art and quality of results, in my opinion, are second to none (commercial or home-built). The engineering and support teams at LifeCanvas are true experts of their technologies and incredibly responsive. I would not hesitate to continue to support their products and service."

"A favorite feature is the ease of use and reliability of the units. All tested specimens worked with no extra optimization or trials on our end. Thin slices of mouse brain were cleared in a matter of a few hours compared to our tests with passive clearing, which took close to a week on the same specimens and produced inferior results with more damage to the tissue. The support from LifeCanvas has been excellent. We had plenty of assistance and guidance available. I would happily recommend the SmartClear system for researchers working in fluorescence microscopy in brain tissues."

"The killer application of optically clearing tissue samples is, for us, that it enables high-throughput study of learning-induced gene expression patterns in the brain. The SmartClear II Pro has made this possible in practice by being well-designed, reliable, and easy to fit into our workflow. The unit clears our mouse hemibrains effectively and rapidly, without browning, and LifeCanvas technical support has been very responsive both regarding the units themselves and in discussing best practices for tissue clearing and sample preparation. I am happy to recommend both LifeCanvas and their products to other scientists with similar needs."

"As an imaging unit that serves a variety of users and applications, one of the best features of this system is that it relies on a simple design, which makes it friendly and suitable for independent use. In addition, the ability to set customized operating parameters makes the system useful in clearing various samples. Unlike other methods that require constant optimization and monitoring, the SmartClear II Pro System allows easy monitoring and documentation of clearing conditions with reproducible results. We would recommend this system for both independent researchers as well as for institutional facilities due to its flexibility, ease of use and the excellent support by LifeCanvas."

"The SmartClear Pro is a quick and efficient way to clear various types of tissue, with little to no optimization required. This system has cleared many mouse and rat organs that include whole brain, liver, uterus horns, kidney, intestine, skin, tongue, heart, pancreas, spleen and has the potential to do many others. The clearing process itself took a few hours to 76 hrs max depending on the tissue, which is far superior than weeks and months of passive clearing required to clear these samples, otherwise. Help was also always provided when required by LifeCanvas, and we would highly recommend this product to researcher looking to image large tissue samples."